- Jennewein Biotechnologie GmbH announces the introduction of a total biosynthesis approach for the production of human milk oligosaccharides (HMOs). Currently the production of HMOs by fermentation requires lactose as a starting material. Lactose is a costly dairy by-product and is difficult to handle in large-scale fermentations. Jennewein Biotechnologie has recently developed processes for the complete biosynthesis of complex HMOs from simple carbon sources rather than lactose. "The introduction of total biosynthesis concepts makes the fermentation process more robust and also more cost effective," states Dr. Stefan Jennewein (CEO). "The last point is particularly relevant because even the most advanced infant formulae contain lower concentrations of HMOs thannatural human milk."Glyn Brookman (Director of Sales) takes up the story: "In order to replace unnecessaryHMO surrogates, like Galactooligosaccharides (GOS) and Fructooligosaccharides (FOS), in infant formulae, the cost of HMOs must be addressed." Dr. Benedikt Engels (Chief Operation Officer) continues: "The new total biosynthesis process will initially replace our current large-scalefermentation process for the production of 2'-fucosyllactose, and will also be used to produce lacto-N-neotetraose." Dr. Stefan Jenneweinsums up the promise of the new technology:"The introduction of our total biosynthesis concept for HMOs is a big leap forward in our mission to bring the significant health benefits of HMOs into every infant formula product for the benefit of all babies." About Jennewein Biotechnologie: Jennewein Biotechnologie is a leading international industrial biotechnology company with a range of products in the field of complex oligosaccharides (HMOs) and rare monosaccharides. The company manufactures an extensive portfolio of innovative HMO products, such as 2'-fucosyllactose, 3'-fucosyllactose and lacto-N-tetraose. These rare sugars are used in the food industry (particularly infant milk formulas), the pharmaceutical industry, and the cosmetic industry. The manufacturing process involves state-of-the-art fermentation techniques. In 2015, the US Food and Drug Administration (FDA) granted Jennewein Biotechnologie a license to market 2'-fucosyllactose in the USA. This was followed in 2017 by European Union marketing authorisation under the Novel Food Regulation. Press contact: Dr. Bettina Gutierrez +49(0)2224-98810-797 bettina.gutierrez@jennewein-biotech.de